Chronic Stress and Health
Chronic stress has long been identified as a determinant of adverse health outcomes. Chronic stress can have many different causes, such as work overload or unemployment, or caring for a family member with chronic illness, to name a few. While many potential mechanisms linking chronic stress with disease have been investigated, many pieces of stress-disease puzzle remain unknown. Here we focus on chronic low-grade inflammation as a pathway linking stress with disease, and we study specifically the psychological and biological determinants of inflammatory disinhibition.
Projects:
Chronischer Stress hat viele negative Konsequenzen. Eine der gravierendsten jedoch besteht in der erhöhten Entzündungsaktivität, die auf chronischen Stress erfolgen kann. Diese Entzündungsprozesse spielen deshalb eine so entscheidende Rolle, da sie wiederum Krankheiten bedingen, die nicht selten zu einer Verringerung der Lebenserwartung führen. Folglich ist es von enormer Bedeutung, Faktoren zu ermitteln, die vor der stressbedingten Erhöhung der Entzündungsparameter und so-mit vor ernsten Krankh…
Cooperating with Prof. George Slavich at the University of California we translated the Stress and Adversity Inventory (STRAIN) into german. STRAIN is an online tool that assesses a person’s exposure to stress over the life course. Differentiating between acute and chronic events it measures frequency, severity and duration of each event. Completing the inventory with more than 200 items takes around 30 minutes.…
In further collaboration with Prof. George Slavich (UCLA) we continue our validation of the German version of the Stress and Adversity Inventory (STRAIN) with parameters of the cardiovascular- and immune system.
STRAIN is an online tool that assesses a person’s exposure to stress over the life course. Differentiating between acute and chronic events, it measures frequency, severity, and duration of each…
Maintenance of physical function, mobility and ability to live independently are important goals for older persons. However, this is counteracted by age-related loss of muscle mass, strength and function. Furthermore, this degenerating process can be reinforced if the older person avoids physical activity and exercise due to fear of falling. We established that fall-related psychological concerns (FrPC) are not only leading to decreased physical activity, but are also associated with elevated levels…
Contact Persons:
Participating Scientists:
- Sarah Sturmbauer
- Nicolas Rohleder
- Sabine Britting
- Robert Kob
- Cornel Sieber
- Ellen Freiberger
Publications:
- Rohleder N.:
Burnout, hair cortisol, and timing: Hyper- or hypocortisolism?
In: Psychoneuroendocrinology (2017)
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2017.10.008 - Chen X., Gianferante D., Hanlin L., Fiksdal A., Breines J., Thoma M., Rohleder N.:
HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity.
In: Psychoneuroendocrinology 78 (2017), p. 168-176
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2017.01.035 - Rohleder N.:
Chronic Stress and Disease
In: Istvan Berczi (ed.): Insights to Neuroimmune Biology, Elsevier Inc., 2016, p. 201-214
ISBN: 9780128017708
DOI: 10.1016/B978-0-12-801770-8.00009-4 - Strahler J., Skoluda N., Rohleder N., Nater U.:
Dysregulated stress signal sensitivity and inflammatory disinhibition as a pathophysiological mechanism of stress-related chronic fatigue.
In: Neuroscience and Biobehavioral Reviews 68 (2016), p. 298-318
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2016.05.008 - Kudielka B., Rohleder N.:
Psychoneuroendocrinological and –immunological changes over the life span [Psychoendokrinologische und -immunologische Veränderungen während der Lebensspanne]
In: Ehlert, U., von Känel, R. (ed.): Psychoendokrinologie und Psychoimmunologie, Heidelberg: Springer, 2011